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January 1, 1998Coronary Artery Disease

Increased baseline levels of platelet P-selectin, and platelet-endothelial cell adhesion molecule-1 in patients with acute myocardial infarction as predictors of unsuccessful thrombolysis

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Why the study?

Do baseline levels of platelet P-selectin and PECAM-1 predict unsuccessful thrombolysis in patients with acute myocardial infarction?

Population

23 patients with acute myocardial infarction enrolled in the GUSTO-III trial

Design

Cohort

Authors

PGPaul A. GurbelInterventional CardiologyVSVictor L. SerebruanyJohns Hopkins UniversityASAndrew R. ShustovSaint Agnes Hospital

Discussion

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Implication

Should not yet guide thrombolysis decisions in AMI; leaves open predictive value pending prospective validation.

Structured PICO

Do baseline levels of platelet P-selectin and PECAM-1 predict unsuccessful thrombolysis in patients with acute myocardial infarction?

P
Population
23 patients with acute myocardial infarction enrolled in the GUSTO-III trial
O
Outcome
Clinical outcome after thrombolysis (failure to reperfuse or recurrent ischemia)hard clinical

Elevated baseline expression of platelet P-selectin and PECAM-1 may serve as predictors for delayed and unsuccessful coronary thrombolysis in patients with acute myocardial infarction.

Cite This Study

Gurbel et al. (1998) studied this question.

synapsesocial.com/papers/6a763eacb4bf63452708753fhttps://doi.org/10.1097/00019501-199809070-00008
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Baseline Platelet Aggregation and Major Receptor Expression Predict Subsequent Activity Following Thrombolysis for Acute Myocardial Infarction2000 · 13 citations
  2. 2Effect of Thrombolytic Therapy on Platelet Expression and Plasma Concentration of PECAM-1 (CD31) in Patients With Acute Myocardial Infarction1999 · 34 citations
  3. 3Prothrombotic markers and early spontaneous recanalization in ST-segment elevation myocardial infarction2007 · 34 citations
  4. 4In Vivoand protease-activated receptor-1-mediated platelet activation in patients presenting for cardiac catheterization2015 · 8 citations
  5. 5Association Between Platelet Receptor Occupancy After Eptifibatide (Integrilin) Therapy and Patency, Myocardial Perfusion, and ST-Segment Resolution Among Patients With ST-Segment–Elevation Myocardial Infarction2004 · 51 citations