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January 1, 2007Thrombosis and HaemostasisOpen Access

Prothrombotic markers and early spontaneous recanalization in ST-segment elevation myocardial infarction

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Why the study?

Are specific prothrombotic biomarkers associated with early spontaneous coronary recanalization in patients with STEMI?

Population

123 patients with ST-segment elevation acute myocardial infarction at the time of emergent coronary…

Design

Case-control

Authors

ÉLÉmilie LanoyInsermDTDidier TchecheLFLaurent J. FeldmanInterventional Cardiology

Discussion

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Implication

These markers should not yet guide STEMI decisions; hypothesis-generating for their role in spontaneous recanalization.

Structured PICO

Are specific prothrombotic biomarkers associated with early spontaneous coronary recanalization in patients with STEMI?

P
Population
123 patients with ST-segment elevation acute myocardial infarction (STEMI) at the time of emergent coronary angiography and before angioplasty, all receiving aspirin and heparin. Includes 53 patients with spontaneous coronary recanalization (cases) and 70 patients with persistent occlusion (controls).
C
Comparator
Persistent occlusion (controls) vs. spontaneous coronary recanalization (cases)
O
Outcome
Levels of prothrombotic biomarkers (soluble P-selectin, PMPs, GMPs, EMPs, TF-MP, sGPV, prothrombin F1 + 2, tPA, PAI-1, PAP)surrogate

Persistent occlusion of the infarct-related artery in STEMI is associated with higher thrombin and plasmin production markers (sGPV and PAP) but not platelet activation markers.

Cite This Study

Lanoy et al. (2007) studied this question.

synapsesocial.com/papers/6a905406f5c79ce9992dacc1https://doi.org/10.1160/th06-11-0621
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