Alpha 1 blockers are highlighted as safe and effective antihypertensive agents that may additionally improve metabolic risk factors such as insulin sensitivity and lipid profiles.
May support alpha-1 blocker use in hypertension with metabolic concerns; leaves open confirmation in prospective RCTs.
Alpha 1 adrenoceptor antagonists are safe, effective, well tolerated drugs which can be used alone or in combination with other drug groups in a wide range of hypertensive patients. Alpha 1 blockers not only lower blood pressure but may improve insulin sensitivity and the adverse lipid profile in many hypertensive patients. In addition to causing few side effects, alpha 1 blockers are not contra-indicated in patients with associated cardiovascular or respiratory disease. Alpha 1 blockers offer the potential to improve the risk factor profile more than conventional antihypertensive drugs.
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JL Reid (1993) studied this question.
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