Why the study?
Does positive pressure ventilation reduce plasma NT-proBNP levels in patients with congestive heart failure and sleep apnea?
Does positive pressure ventilation reduce plasma NT-proBNP levels in patients with congestive heart failure and sleep apnea?
Short-term positive pressure ventilation significantly reduces plasma NT-proBNP levels and improves oxygen saturation in patients with congestive heart failure and sleep apnea.
Short-term PPV lowers NT-proBNP in HF with sleep apnea; confirms acute biomarker effect but requires outcome trials.
BACKGROUND: The purpose of the present study was to assess the short-term effects of positive pressure ventilation (PPV) on plasma amino terminal-pro brain natriuretic peptide (NT-proBNP) levels in patients with congestive heart failure (CHF) and sleep apnea (SA). METHODS AND RESULTS: Polysomnography was performed in 105 CHF patients. Twenty-six patients with CHF and SA were randomly assigned to a control group or a PPV group. Patients in the higher New York Heart Association classes had higher plasma levels of NT-proBNP. The plasma NT-proBNP concentration in the PPV group decreased. CONCLUSION: Plasma NT-proBNP levels reflect the severity of CHF, and PPV can decrease plasma NT-proBNP levels in patients with CHF and SA.
No takes yet. Share an insight, caveat, or question.
Zhao et al. (2006) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: