Why the study?
While animal models highlight the benefits of exercise on cancer treatment-related cardiac dysfunction, few clinical studies have explored exercise-based interventions in childhood and adolescent cancer survivors.
Do exercise-based interventions improve cancer treatment-related cardiac dysfunction in childhood and adolescent cancer survivors?
Do exercise-based interventions improve cancer treatment-related cardiac dysfunction in childhood and adolescent cancer survivors?
Exercise interventions may have positive effects on managing cardiotoxicity in pediatric cancer survivors, but more clinical research is needed.
Few human trials exist despite preclinical promise; leaves open exercise as adjunct to dexrazoxane in survivors.
Childhood and adolescent cancer survivors are disproportionately more likely to develop cardiovascular diseases from the late effects of cardiotoxic therapies (e.g., anthracycline-based chemotherapy and chest-directed radiotherapy). Currently, dexrazoxane is the only approved drug for preventing cancer treatment-related cardiac damage. While animal models highlight the beneficial effects of exercise cancer treatment-related cardiac dysfunction, few clinical studies have been conducted. Thus, the objective of this scoping review was to explore the designs and impact of exercise-based interventions for managing cancer treatment-related cardiac dysfunction in childhood and adolescent cancer survivors. Reviewers used Joanna Briggs Institute's methodology to identify relevant literature. Then, 4616 studies were screened, and three reviewers extracted relevant data from six reports. Reviewers found that exercise interventions to prevent cancer treatment-related cardiac dysfunction in childhood and adolescent cancer survivors vary regarding frequency, intensity, time, and type of exercise intervention. Further, the review suggests that exercise promotes positive effects on managing cancer treatment-related cardiac dysfunction across numerous indices of heart health. However, the few clinical studies employing exercise interventions for childhood and adolescent cancer survivors highlight the necessity for more research in this area.
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Kendall et al. (2022) studied this question.
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