Key result
Essential hypertension is linked to decreased erythrocyte calcium uptake and impaired ionophore equilibration.
Case-Control
Decreased 45calcium uptake was observed in red cells of 20 patients with essential hypertension. Equilibration of extracellular 45calcium with intracellular calcium was not achieved within 60 min in red cells of either hypertensive patients or control subjects. By introducing the ionophore A23187, equilibrium conditions were attained for red cells of both categories of individuals. Still the discrepancy in 45calcium uptake was preserved between them. These results support the view that red cells of hypertensive patients have an altered membrane permeability to calcium, possibly reflecting also a greater exchangeable pool of cytosolic free calcium.
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Ronquist et al. (1988) conducted a case-control in Essential hypertension. Essential hypertension (in vitro red cell 45calcium and ionophore A23187 exposure) vs. Control subjects was evaluated on Red cell 45calcium uptake and equilibration. Red cells from 20 patients with essential hypertension showed decreased 45calcium uptake compared to controls after 60 min and following ionophore A23187 equilibration.
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