Why the study?
Does lowering arterial pressure with captopril or hydralazine improve minimal coronary vascular resistance in SHR and WKY rats?
Population
Six-month-old spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats
Comparison
Captopril or hydralazine for a period of 3 months vs Untreated controls
Design
Preclinical
Follow-up
3 months
Authors
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Captopril may lower minimal coronary vascular resistance in hypertensive rat models; hypothesis-generating and leaves open human translation.
Does lowering arterial pressure with captopril or hydralazine improve minimal coronary vascular resistance in SHR and WKY rats?
Improvement in minimal coronary vascular resistance is related to both the regression of left ventricular hypertrophy and the lowering of arterial systolic pressure, as demonstrated by captopril treatment in rats.
Canby et al. (1989) studied this question.
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