What question did this study set out to answer?

To determine whether antihypertensive therapies that lower blood pressure equally exert different effects on the structural regression of resistance vessel wall hypertrophy.

March 1, 1987Circulation

Differential structural responses of small resistance vessels to antihypertensive therapy.

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Why the study?

Does captopril plus hydrochlorothiazide or hydralazine reduce resistance vessel hypertrophy and left ventricular weight in spontaneously hypertensive rats?

Population

Spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY)

Comparison

Hydralazine or captopril combined with… vs Untreated SHR and WKY

Design

Preclinical

Follow-up

12 weeks

Authors

TSTsuneji SanoHiroshima University RTRobert C. TaraziGeneral / Preventive / Lipids

Discussion

Member takes

Implication

Captopril-HCTZ but not hydralazine reduces vascular and LV hypertrophy beyond BP effects in SHR; leaves open human translation.

Key Points

To determine whether antihypertensive therapies that lower blood pressure equally exert different effects on the structural regression of resistance vessel wall hypertrophy.
Spontaneously hypertensive rats (SHR) were treated for 12 weeks with hydralazine alone or captopril combined with hydrochlorothiazide, and compared with untreated SHR and normotensive Wistar-Kyoto (WKY) controls.
Hindlimb perfusion pressure was assessed in pithed rats under constant blood flow (4.0 ml/min) and maximal vasodilation (hemodilution to 22% hematocrit, nitroprusside, and papaverine) as an index of vessel wall thickening.
Perfusion pressure was 26.8 ± 0.4 mm Hg in untreated WKY (n = 12) versus 37.6 ± 0.4 mm Hg in untreated SHR (n = 11; p < 0.01), indicating marked baseline resistance vessel hypertrophy.
Both regimens controlled blood pressure equally, but perfusion pressure dropped significantly to 34.0 ± 0.5 mm Hg with captopril-hydrochlorothiazide (p < 0.01) while remaining largely unreversed at 36.5 ± 0.5 mm Hg with hydralazine.
Left ventricular weight was reduced from 2.63 ± 0.05 mg/g in untreated SHR to 2.02 ± 0.02 mg/g with captopril-hydrochlorothiazide (p < 0.01), compared to only 2.44 ± 0.05 mg/g with hydralazine.

Structured PICO

Does captopril plus hydrochlorothiazide or hydralazine reduce resistance vessel hypertrophy and left ventricular weight in spontaneously hypertensive rats?

Population

Spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY)

Intervention

Hydralazine or captopril combined with hydrochlorothiazide for 12 weeks

Comparator

Untreated SHR and WKY

Outcome

Perfusion pressure in the hindlimbs (index of resistance vessel hypertrophy) and left ventricular weightsurrogate

Captopril combined with hydrochlorothiazide, but not hydralazine, significantly reverses resistance vessel hypertrophy and left ventricular hypertrophy in spontaneously hypertensive rats despite equal blood pressure control.

Cite This Study

Sano et al. (1987) studied this question.

synapsesocial.com/papers/6a8299dbc00c8d0185b27fb2 https://doi.org/10.1161/01.cir.75.3.618

Topics

Hypertension management

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Differential structural responses of small resistance vessels to antihypertensive therapy.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Differential structural responses of small resistance vessels to antihypertensive therapy.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

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