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March 15, 2021AntioxidantsOpen Access

Balanced Intense Exercise Training Induces Atrial Oxidative Stress Counterbalanced by the Antioxidant System and Atrial Hypertrophy That Is Not Associated with Pathological Remodeling or Arrhythmogenicity

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Why the study?

Vigorous exercise has been linked to an increased risk of atrial arrhythmias related to oxidative stress, but exercise-induced atrial remodeling and sex-specific differences remained unclear.

Does a 12-week swim training protocol induce pathological atrial remodeling or arrhythmogenicity in young adult rats?

Population

Age-matched young adult rats

Comparison

12-week swim training protocol vs control in male and female rats

Design

Preclinical animal study

Follow-up

12 weeks

Authors

AOAttila OláhSemmelweis UniversityBBBálint András BartaSemmelweis UniversityASAlex Ali SayourSemmelweis University

Discussion

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Overview

Oxidative stress-linked atrial remodeling in exercised rats warrants caution in vigorous training; leaves open human translation and sex-specific therapies.

Structured PICO

Does a 12-week swim training protocol induce pathological atrial remodeling or arrhythmogenicity in young adult rats?

P
Population
Age-matched young adult rats (female and male)
I
Intervention
12-week-long swim training protocol
C
Comparator
Control group (female and male)
O
Outcome
Atrial remodeling (hypertrophy, oxidative stress, electrophysiology, arrhythmogenicity)surrogate

Long-term intense exercise in a rat model induces physiological atrial hypertrophy without causing pathological remodeling or arrhythmias.

Cite This Study

Oláh et al. (2021) studied this question.

synapsesocial.com/papers/6a764a168cd3ec459188067bhttps://doi.org/10.3390/antiox10030452
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Also Consider

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  5. 5Atrial remodelling is less pronounced in female endurance-trained athletes compared with that in male athletes2013 · 25 citations