February 1, 1989The Journal of PhysiologyOpen Access

Reorganization of sympathetic preganglionic connections in cat bladder ganglia following parasympathetic denervation.

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Population

Cats with chronic unilateral parasympathetic preganglionic denervation of the bladder

Comparison

Electrical stimulation of the hypogastric nerve vs Cats with intact bladder innervation or the…

Design

Preclinical

Follow-up

3-22 months

Authors

WGWilliam C. de GroatJikei University School of Medicine MKMakoto KawataniRIKEN Center for Sustainable Resource Science

Discussion

Member takes

Implication

Supports autonomic plasticity after preganglionic denervation; leaves open therapeutic translation to neurogenic bladder in humans.

Structured PICO

Population

Cats with chronic unilateral parasympathetic preganglionic denervation of the bladder

Intervention

Electrical stimulation (10-30 Hz) of the hypogastric nerve

Comparator

Cats with intact bladder innervation or the normally innervated side of the bladder in unilaterally denervated preparations

Outcome

Bladder contractions and postganglionic nerve firingsurrogate

Parasympathetic preganglionic denervation of the bladder ganglia leads to reinnervation by sympathetic preganglionic pathways, converting sympathetic inhibitory pathways to excitatory pathways.

Cite This Study

Groat et al. (1989) studied this question.

synapsesocial.com/papers/6a764af259770ea2c0bcb8fb https://doi.org/10.1113/jphysiol.1989.sp017506

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Reorganization of sympathetic preganglionic connections in cat bladder ganglia following parasympathetic denervation.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Reorganization of sympathetic preganglionic connections in cat bladder ganglia following parasympathetic denervation.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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