Why the study?
Does tirofiban infusion resolve left ventricular mobile thrombus in a patient with severe left ventricular dysfunction?
Does tirofiban infusion resolve left ventricular mobile thrombus in a patient with severe left ventricular dysfunction?
Tirofiban infusion may be an effective medical alternative for resolving left ventricular mobile thrombi in patients who refuse or are poor candidates for surgery.
May support tirofiban for LV thrombus in poor surgical candidates; single case report leaves open efficacy and safety.
A 28-year-old man was admitted with symptoms of heart failure. Echocardiography revealed severe left ventricular dysfunction, apical aneurysm, and a 40 × 11 mm sized mobile thrombus attached to apical septum with a narrow stalk. The patient had anterior myocardial infarction two years ago. Heparin infusion was started at 1000 IU/hour for 48 hours. There was no detected change on the size of the thrombus. Surgery recommended to the patient was refused by him because of the procedural risks. Tirofiban infusion was started. Repeat echocardiography showed significant reduction in thrombus size after 24 hours, and complete resolution of the thrombus after 48 hours. To our knowledge, this is the first case with left ventricular mobile thrombus treated successfully with tirofiban infusion.
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Çil et al. (2013) studied this question.
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