What question did this study set out to answer?

To determine whether native T1 mapping can quantitatively characterize myocardial tissue abnormalities in patients with left ventricular non-compaction in comparison with late gadolinium enhancement.

January 1, 2016Circulation JournalOpen Access

Characterization of Compacted Myocardial Abnormalities by Cardiac Magnetic Resonance With Native T1 Mapping in Left Ventricular Non-Compaction Patients　– A Comparison With Late Gadolinium Enhancement –

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Why the study?

Does native T1 mapping improve the detection of myocardial fibrosis compared to late gadolinium enhancement in patients with left ventricular non-compaction?

Population

31 patients with left ventricular non-compaction (LVNC) and 8 normal controls

Comparison

Cardiac magnetic resonance with native T1 mapping vs Late gadolinium enhancement (LGE) imaging

Design

Cross-sectional

Authors

HZHongmei ZhouBGI Group (China)XLXue LinSichuan University LFLigang FangUniversity of Vienna

Discussion

Member takes

Implication

Native T1 mapping may identify myocardial abnormalities in LVNC beyond LGE; leaves open its prognostic utility pending prospective studies.

Key Points

To determine whether native T1 mapping can quantitatively characterize myocardial tissue abnormalities in patients with left ventricular non-compaction in comparison with late gadolinium enhancement.
Enrolled 31 patients with left ventricular non-compaction (14 with late gadolinium enhancement) and 8 healthy controls.
Conducted cardiovascular magnetic resonance imaging to obtain native T1 maps and late gadolinium enhancement images.
Compared native T1 values across patient subgroups and evaluated native T1 as a predictor of late gadolinium enhancement using unadjusted and multivariable logistic regression.
Native T1 values differed significantly across cohorts (F=9.74, P<0.001), measuring 1,098.8±40.8 ms in normal controls, 1,140.6±32.8 ms in LGE(-) patients, and 1,181.4±53.7 ms in LGE(+) patients.
Each 1 standard deviation increase in native T1 was significantly associated with the presence of late gadolinium enhancement before (OR 2.966, 95% CI: 1.123–7.835, P=0.028) and after adjusting for confounders (adjusted OR 4.348, 95% CI: 1.155–16.363, P=0.030).

Structured PICO

Does native T1 mapping improve the detection of myocardial fibrosis compared to late gadolinium enhancement in patients with left ventricular non-compaction?

Population

31 patients with left ventricular non-compaction (LVNC) and 8 normal controls

Intervention

Cardiac magnetic resonance with native T1 mapping

Comparator

Late gadolinium enhancement (LGE) imaging

Outcome

Native T1 values and discrimination of the presence of LGEsurrogate

Native T1 mapping may detect myocardial abnormalities in LVNC patients earlier and with greater sensitivity than late gadolinium enhancement.

Cite This Study

Zhou et al. (2016) studied this question.

synapsesocial.com/papers/6a764c5d8ffa56f63806deb6 https://doi.org/10.1253/circj.cj-15-1269

Topics

Cardiac MRI

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Implication

Native T1 mapping may identify myocardial abnormalities in LVNC beyond LGE; leaves open its prognostic utility pending prospective studies.

Characterization of Compacted Myocardial Abnormalities by Cardiac Magnetic Resonance With Native T1 Mapping in Left Ventricular Non-Compaction Patients　– A Comparison With Late Gadolinium Enhancement –

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Characterization of Compacted Myocardial Abnormalities by Cardiac Magnetic Resonance With Native T1 Mapping in Left Ventricular Non-Compaction Patients　– A Comparison With Late Gadolinium Enhancement –

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider

Characterization of Compacted Myocardial Abnormalities by Cardiac Magnetic Resonance With Native T1 Mapping in Left Ventricular Non-Compaction Patients – A Comparison With Late Gadolinium Enhancement –

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Characterization of Compacted Myocardial Abnormalities by Cardiac Magnetic Resonance With Native T1 Mapping in Left Ventricular Non-Compaction Patients – A Comparison With Late Gadolinium Enhancement –

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider

Characterization of Compacted Myocardial Abnormalities by Cardiac Magnetic Resonance With Native T1 Mapping in Left Ventricular Non-Compaction Patients　– A Comparison With Late Gadolinium Enhancement –

Characterization of Compacted Myocardial Abnormalities by Cardiac Magnetic Resonance With Native T1 Mapping in Left Ventricular Non-Compaction Patients　– A Comparison With Late Gadolinium Enhancement –