Why the study?
Does ablation of MMP9 enhance the survival and differentiation of cardiac stem cells into cardiomyocytes in diabetic mice?
Population
Ins2(+/-) Akita (diabetic), C57 BL/6J (wild type), and double knock out (DKO: Ins2(+/-)/MMP9(-/-)) mice
Comparison
Ablation of MMP9 (genetic knockout) vs Ins2 Akita and C57 BL/6J mice
Design
Preclinical
Authors
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Does not support clinical use; leaves open MMP9 targeting for cardiac regeneration in diabetes.
Does ablation of MMP9 enhance the survival and differentiation of cardiac stem cells into cardiomyocytes in diabetic mice?
Ablation of MMP9 in diabetic mice reduces cardiac fibrosis and promotes the survival and differentiation of cardiac stem cells into cardiomyocytes.
Mishra et al. (2012) studied this question.
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