Key result
MMP-9 gene ablation prevented increased endocardial endothelial apoptosis and ameliorated impaired cardiac function in mice with chronic volume overload heart failure.
Why the study?
Does MMP-9 gene ablation prevent endocardial endothelial apoptosis and cardiac dysfunction in a mouse model of chronic volume overload heart failure?
Population
12 mice (FVB/NJ wild type and MMP-9 knockout FVB.Cg-MMP9/J) divided into 4 groups: wild type sham, MMP-9KO…
Comparison
MMP-9 gene ablation (MMP-9 knockout) vs Wild type mice with arteriovenous fistula and…
Design
Preclinical
Follow-up
8 weeks
Authors
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Should not change clinical practice; hypothesis-generating for MMP-9 targeting in volume-overload HF models.
Does MMP-9 gene ablation prevent endocardial endothelial apoptosis and cardiac dysfunction in a mouse model of chronic volume overload heart failure?
MMP-9 gene ablation ameliorates cardiac dysfunction and endocardial endothelial apoptosis in a mouse model of volume overload heart failure.
Ovechkin et al. (2005) studied Chronic volume overload congestive heart failure (n=12). MMP-9 gene ablation vs. Wild type control was evaluated on Heart function and endocardial endothelial apoptosis. MMP-9 gene ablation prevented increased endocardial endothelial apoptosis and ameliorated impaired cardiac function in mice with chronic volume overload heart failure.
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