Key result
In a mouse model of aortic stenosis, compensatory hypertrophy featured increased MMP-2 and vascularization, whereas decompensatory heart failure exhibited increased MMP-9 and vascular rarefaction.
Population
Wild type (WT) and MMP-9-/- (MMP-9KO) mice
Comparison
Aortic stenosis created by banding the ascending… vs Sham operated mice
Design
Preclinical
Follow-up
8 weeks
Authors
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No immediate clinical implications for aortic stenosis; hypothesis-generating for MMP-2/9 isoform targeting in human progression.
The transition from compensatory hypertrophy to decompensatory heart failure involves a shift from MMP-2-mediated angiogenesis to MMP-9/TIMP-3-mediated vascular rarefaction.
Givvimani et al. (2010) studied Aortic stenosis and heart failure. Aortic stenosis via ascending aorta banding vs. Sham operated mice was evaluated on Cardiac function, MMP/TIMP levels, and vascularization. In a mouse model of aortic stenosis, compensatory hypertrophy featured increased MMP-2 and vascularization, whereas decompensatory heart failure exhibited increased MMP-9 and vascular rarefaction.
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