Population
beta1 subunit knockout (beta1-/-) mice and wild type mice (native myocytes)
Comparison
tamoxifen, 4-OH tamoxifen, and 17beta-estradiol vs wild type myocytes (or untreated baseline)
Design
Preclinical
Authors
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Identifies beta1 as essential for (xeno)estrogen effects on BK channels in murine myocytes; leaves open relevance to human vascular physiology.
The regulatory beta1 subunit is essential for the activation of smooth muscle BK channels by physiological estrogens and pharmacological xenoestrogens.
Dick et al. (2001) studied this question.
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