Population
36 rats: 9 weanling normotensive spontaneously hypertensive rats, 9 adult hypertensive SHR, 9 weanling…
Comparison
Normal (0.4% sodium) diet vs Age-matched normotensive Wistar-Kyoto rats and…
Design
Preclinical
Authors
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Hypothesis-generating for early renal Na+-K+-ATPase activation in hypertension; leaves open human translation and clinical relevance.
The renin-angiotensin-aldosterone system and renal Na+-K+-ATPase activity are activated in spontaneously hypertensive rats prior to blood pressure elevation, suggesting a renal role in the initiation of hypertension.
Cangiano et al. (1984) studied this question.
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