What question did this study set out to answer?

To determine whether propofol-induced electroencephalographic burst suppression provides neuroprotection and preserves postoperative neuropsychological function during open heart valve surgery.

May 1, 1999AnesthesiologyOpen Access

Ineffectiveness of Burst Suppression Therapy in Mitigating Perioperative Cerebrovascular Dysfunction

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Authors

GRGary W. RoachAmbulance Service of New South Wales MNMark F. NewmanSt. Luke's-Roosevelt Hospital Center JMJohn M. MurkinWestern University

Discussion

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Implication

Randomized trial demonstrates propofol burst suppression fails to improve neurological outcomes in cardiac valve surgery, indicating metabolic suppression does not provide neuroprotection.

Key Points

To determine whether propofol-induced electroencephalographic burst suppression provides neuroprotection and preserves postoperative neuropsychological function during open heart valve surgery.
Randomized trial of 225 patients undergoing cardiac valve surgery assigned to standard sufentanil anesthesia (n=116) or sufentanil plus propofol titrated to electroencephalographic burst suppression (n=109).
Blinded assessments of neurologic and neuropsychologic function conducted at baseline, postoperative day 1 (neurologic only), days 5–7, and days 50–70, benchmarked against 40 age- and education-matched nonsurgical controls.
Adverse neurologic outcome rates between propofol and control groups were 40% versus 25% at postoperative day 1 (P = 0.06), 18% versus 8% at days 5–7 (P = 0.07), and 6% versus 6% at days 50–70 (P = 0.80).
Postoperative neuropsychological impairment rates were 91% for propofol versus 92% for controls at days 5–7, decreasing to 52% versus 47% at days 50–70, with no significant differences in severity, depression, or anxiety scores.

Cite This Study

Roach et al. (1999) studied this question.

synapsesocial.com/papers/6a7653d970b84e52bb8802be https://doi.org/10.1097/00000542-199905000-00006

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Implication

Randomized trial demonstrates propofol burst suppression fails to improve neurological outcomes in cardiac valve surgery, indicating metabolic suppression does not provide neuroprotection.

Ineffectiveness of Burst Suppression Therapy in Mitigating Perioperative Cerebrovascular Dysfunction

Discussion

Member takes

Implication

Key Points

Cite This Study

Ineffectiveness of Burst Suppression Therapy in Mitigating Perioperative Cerebrovascular Dysfunction

Discussion

Member takes

Implication

Key Points

Cite This Study

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