Why the study?
Does heparin administration increase free fatty acids and oxygen consumption in obese and lean subjects?
Does heparin administration increase free fatty acids and oxygen consumption in obese and lean subjects?
Heparin increases free fatty acids and oxygen consumption, suggesting a potential metabolic disadvantage in conditions like myocardial infarction due to increased metabolic demand.
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May increase metabolic demand via elevated FFAs in MI; hypothesis-generating and should not yet change practice.
Obese and lean subjects were given heparin with or without Intralipid in order to assess the effect of heparin on plasma concentration of free fatty acids (FFA) and oxidative metabolism. The FFA response depended on the triglyceride concentration and was associated with a prompt rise in oxygen consumption. Plasma catecholamines did not alter after heparin and the increase in oxygen uptake was proportional to the rise in FFA. The use of heparin, therefore, has metabolic disadvantages which may outweigh the potential benefits, for example in the management of myocardial infarction where heparin may increase the metabolic demand on the heart by increasing FFA levels.
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Jung et al. (1980) studied this question.
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