Why the study?
The prevalence, reliability of diagnostic modalities, independent predictors, and clinical outcomes of acute myocardial injury associated with COVID-19 remained uncertain and debated.
Does acute myocardial injury increase mortality in hospitalized patients with COVID-19?
Does acute myocardial injury increase mortality in hospitalized patients with COVID-19?
Acute myocardial injury affects over one-fifth of hospitalized COVID-19 patients and is associated with an eight-fold increase in mortality, highlighting the need for early detection and management.
Myocardial injury in COVID-19 warrants heightened cardiac surveillance in practice; meta-analysis reinforces its prognostic importance while leaving causal pathways open for targeted trials.
Background: The body of evidence showed that there is a strong correlation between acute myocardial Injury and COVID-19 infection. However, the link between acute myocardial infection and COVID-19, the prevalence, reliability of diagnostic modalities, independent predictors, and clinical outcomes are still uncertain and a topic of debate. The current study was designed to determine the prevalence, determinants, and outcomes of acute myocardial injury based on a systematic review and meta-analysis the global published peer-reviewed works of literature. Methods: A comprehensive search was conducted in PubMed/Medline; Science direct, CINHAL, and LILACS from December 2019 to May 2021. All observational studies reporting the prevalence of AMI were included while case reports and reviews were excluded. The data were extracted with two independent authors in a customized format. The methodological quality of included studies was evaluated using the Newcastle-Ottawa appraisal tool. Results: A total of 397 articles were identified from different databases. Thirty-seven Articles with 21, 204 participants were included while seven studies were excluded. The meta-analysis revealed that the pooled prevalence of myocardial injury during the COVID-19 pandemic was 22.33 % (95 % CI: 17.86 to 26.81, 37). Conclusion: Our meta-analysis showed that mortality among patients with an acute myocardial injury during COVID-19 was more than four times more likely as compared to those without AMI. This necessitates a mitigating strategy to prevent and manage before its clinical outcomes getting worse. HIGHLIGHTS The meta-analysis revealed that more than one-fifth of patients with COVID-19 sustained AMI The incidence of mortality among patients with AMI during COVID-19 pandemic was four times more likely as compared those without AMI Prevalence of AMI was three times more likely in patients with history of Coronary artery disease Smoking and hypertension were the independent predictors of acute myocardial Injury
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Abate et al. (2021) studied this question.
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