Population
Two different cell systems, including human hepatoma cell lines
Design
Preclinical
Authors
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Identifies separable G-CSFR domains in animals; leaves open human translation and selective therapeutic targeting.
The cytoplasmic domain of the G-CSFR contains distinct functional regions for proliferation and gene induction, sharing a signal transduction pathway with interleukin-6.
Ziegler et al. (1993) studied this question.
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