January 28, 2014Psychosomatic Medicine
Effect of Depression and Sertraline Treatment on Cardiac Function in Female Nonhuman Primates
Why the study?
Does sertraline treatment alter cardiac structural and functional phenotypes in female cynomolgus monkeys?
Population
42 adult female cynomolgus monkeys that consumed a Western-like diet for 3 years, with depressive behavior…
Comparison
Sertraline HCl for 18 months vs No sertraline treatment (half of the monkeys)
Design
Preclinical
Follow-up
18 months
Authors
Discussion
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Member takes
Implication
Sertraline does not impair function in this primate model; leaves open translation to human depression or HF management.
Structured PICO
Does sertraline treatment alter cardiac structural and functional phenotypes in female cynomolgus monkeys?
P
Population
42 adult female cynomolgus monkeys that consumed a Western-like diet for 3 years, with depressive behavior assessed for 12 months before echocardiography.
I
Intervention
Sertraline HCl for 18 months
C
Comparator
No sertraline treatment (half of the monkeys)
O
Outcome
Cardiac structural and functional phenotypes assessed by transthoracic echocardiographysurrogate
In a primate model, behavioral depression is associated with altered cardiac function (higher heart rate and smaller volumes), and sertraline treatment reduces heart rate and increases chamber dimensions without overtly affecting systolic or diastolic function.
Cite This Study
Groban et al. (2014) studied this question.