Why the study?
Does added insulin alter the time-course of glucose utilization in the isolated perfused rat heart?
Population
Isolated perfused rat heart
Comparison
Added insulin (100 mU/ml) vs Absence of added insulin
Design
Preclinical
Follow-up
up to one hour
Authors
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Residual insulin carryover may confound perfusion studies; leaves open translation beyond rat models.
Does added insulin alter the time-course of glucose utilization in the isolated perfused rat heart?
Endogenous insulin influences the metabolic properties of the isolated perfused rat heart longer than generally supposed, affecting the time-course of glucose utilization.
Fisher et al. (1972) studied this question.
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