The human autoantigen La/SS-B acts as a cellular factor that facilitates herpes simplex virus type 1 replication in mouse 3T3 cells.
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La/SS-B may act as a host factor for HSV-1; hypothesis-generating for antiviral targeting in humans.
Permanently transfected mouse cell lines which expressed different levels of the human autoantigen La/SS-B were infected with different strains of herpes simplex virus type 1, including the strains ANG, HSZP, 17syn+ and HFEM. During infection the localization of the human La protein was followed using an anti-La MoAb, which recognized only the human La protein but did not cross-react with either the endogenous mouse La protein or any viral encoded protein. After infection La protein was transported from the nucleus to the cytoplasm. The time course of translocation was dependent on the amount of human La protein expressed in the respective cell line. Moreover, acceleration of viral replication was dependent on the level of expression of human La protein, suggesting that La protein is a cellular factor that facilitates virus replication.
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Bachmann et al. (1998) studied this question.
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