Key result
Isolated anti-Ro antibodies in SLE are linked to ~6-fold higher rates of serious renal disease.
Observational (n=55)
Reveals distinct clinical and serological subsets in systemic lupus erythematosus, indicating that anti-Ro alone carries a higher risk of nephritis than anti-Ro with anti-La.
Among 55 systemic lupus erythematosus patients having antibodies to Ro and/or La, two major groups were distinguished by titration of sera in counterimmunoelectrophoresis. The first group (30 patients) had antibodies to Ro alone. This was associated with a high incidence of antibodies to DNA (77%) and serious renal disease (53%). The second group (23 patients) had antibodies to Ro and La, and this was associated with a lower incidence of antibodies to DNA (30%) and a very low incidence of nephritis (9%). In this group a phenomenon of linkage of anti- Ro and anti-La titers was observed. Additionally two patients with only anti-La were found. Neither had clinically apparent renal disease. Thus, systemic lupus erythematosus patients with anti-Ro fall into two subgroups that differ considerably in their prevalence of anti-DNA and serious renal disease.
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Wasicek et al. (1982) conducted an observational in Systemic lupus erythematosus (n=55). Antibodies to Ro alone vs. Antibodies to Ro and La was evaluated on Serious renal disease / nephritis. Antibodies to Ro alone in SLE patients were associated with higher rates of serious renal disease (53% vs 9%) and anti-DNA antibodies (77% vs 30%) compared to antibodies to both Ro and La.
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