October 1, 1991Clinical & Experimental ImmunologyOpen Access

Detection and occurrence of the 60- and 52-kD Ro (SS-A) antigens and of autoantibodies against these proteins

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Population

Sera from 38 patients with systemic lupus erythematosus and 26 patients with Sjögren's syndrome, as well as…

Design

Preclinical

Authors

RSRob L. Slobbe GPGer J.M. PruijnRadboud University Nijmegen WDWim G.M. DamenFriedrich Schiller University Jena

Discussion

Member takes

Implication

Anti-Ro subtype patterns may aid clinical differentiation of Sjögren's from SLE; animal data leave open mechanistic roles in ribonucleoprotein complexes.

Structured PICO

Population

Sera from 38 patients with systemic lupus erythematosus (SLE) and 26 patients with Sjögren's syndrome, as well as HeLa cell extracts and various mammalian cell lines.

Intervention

Immunoblotting with an acrylamide/bisacrylamide ratio of 19:1, double immunofluorescence microscopy, and immunoprecipitation.

Outcome

Detection and occurrence of anti-La, anti-60-kD Ro, and anti-52-kD Ro antibodies, and localization/conservation of the antigens.surrogate

Specific patterns of anti-Ro antibodies differentiate between Sjögren's syndrome and SLE, and the 52-kD and 60-kD Ro proteins co-localize in ribonucleoprotein complexes.

Cite This Study

Slobbe et al. (1991) studied this question.

synapsesocial.com/papers/6a7d8f65c2b228f3e18c91de https://doi.org/10.1111/j.1365-2249.1991.tb05780.x

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Implication

Anti-Ro subtype patterns may aid clinical differentiation of Sjögren's from SLE; animal data leave open mechanistic roles in ribonucleoprotein complexes.

Detection and occurrence of the 60- and 52-kD Ro (SS-A) antigens and of autoantibodies against these proteins

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Detection and occurrence of the 60- and 52-kD Ro (SS-A) antigens and of autoantibodies against these proteins

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider