Why the study?
Obesity at diagnosis of childhood ALL is associated with greater relapse risk, but whether this association extends to obesity during maintenance therapy is unstudied.
Does extreme obesity during maintenance therapy increase the risk of relapse in children with acute lymphoblastic leukemia?
Population
676 children with ALL during maintenance therapy
Comparison
Extreme obesity vs overweight/obese vs normal/underweight BMI percentiles
Design
Cohort study using data from AALL03N1
Follow-up
Median 7.9 years
Authors
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Extreme obesity during ALL maintenance was associated with higher relapse risk; leaves open whether weight interventions during therapy improve outcomes.
Does extreme obesity during maintenance therapy increase the risk of relapse in children with acute lymphoblastic leukemia?
Extreme obesity during maintenance therapy is associated with a 2.4-fold greater hazard of relapse in children with acute lymphoblastic leukemia.
Wadhwa et al. (2022) studied this question.
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