Population
30 male Hsd:ICR (CD-1) mice, 6 weeks of age (10 control, 10 STZ-induced T1DM, 10 STZ-induced T1DM + insulin)
Comparison
Streptozotocin 200 mg/kg single intraperitoneal… vs Citrate buffer single intraperitoneal injection
Design
Preclinical, Semi-quantitative analysis of immunoreactivity evaluated in a…
Follow-up
7 days
Authors
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May support UAGT as early intrarenal RAS marker in diabetic models; leaves open human validation before clinical use.
Urinary angiotensinogen increases earlier than urinary albumin in experimental type 1 diabetes, suggesting its potential as a novel early biomarker for intrarenal renin-angiotensin system activation.
Kamiyama et al. (2012) studied this question.
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