December 1, 1995Journal of Clinical InvestigationOpen Access

Cholesterol efflux potential of sera from mice expressing human cholesteryl ester transfer protein and/or human apolipoprotein AI.

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Why the study?

Does the expression of human apo AI and/or CETP alter the cholesterol efflux potential of sera in transgenic mice?

Structured PICO

Does the expression of human apo AI and/or CETP alter the cholesterol efflux potential of sera in transgenic mice?

Population

Transgenic mice expressing human apolipoprotein AI (HuAITg), human cholesteryl ester transfer protein (HuCETPTg), both (HuAICETPTg), apo AI knockout mice (AI KO), and background/control mice (n=117 total).

Intervention

Expression of human apolipoprotein AI (apo AI) and/or human cholesteryl ester transfer protein (CETP)

Comparator

Background/control mice (C57BLxCBA hybrids)

Outcome

Percent cholesterol efflux from Fu5AH donor cells to 5% sera in 4 hourssurrogate

Coexpression of human apo AI and CETP improves the efficiency of HDL particles as cholesterol acceptors compared to human apo AI expression alone in transgenic mice.

Discussion

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Implication

Human apoAI/CETP transgenes modify HDL efflux capacity in mice; hypothesis-generating for human HDL function, needs clinical validation.

Cite This Study

Atger et al. (1995) studied this question.

synapsesocial.com/papers/6a766550656dd99464ec021f https://doi.org/10.1172/jci118326

View Full Paper

Ask AI

Bookmark

Cholesterol efflux potential of sera from mice expressing human cholesteryl ester transfer protein and/or human apolipoprotein AI.

Structured PICO

Discussion

Implication

Cite This Study

Cholesterol efflux potential of sera from mice expressing human cholesteryl ester transfer protein and/or human apolipoprotein AI.

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider