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December 1, 1982ThoraxOpen Access

Pulmonary vascular and alveolar development in tetralogy of Fallot: a recommendation for early correction.

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Population

7 children aged 1.2-12 years who died during or soon after repair of tetralogy of Fallot.

Design

Case_series

Authors

RJRobert J. JohnsonSHSheila G. Haworth

Discussion

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Overview

Abnormal lung development in TOF may affect repair timing; hypothesis-generating from Level 5 data and requires prospective validation.

Structured PICO

P
Population
7 children aged 1.2-12 years who died during or soon after repair of tetralogy of Fallot.
O
Outcome
Pulmonary arterial and alveolar development (lung volume, alveolar size and number, arterial structure)surrogate

Postmortem morphometric analysis reveals abnormal pulmonary arterial and alveolar development in children with tetralogy of Fallot, supporting the recommendation for early surgical correction.

Cite This Study

Johnson et al. (1982) studied this question.

synapsesocial.com/papers/6a766d2a98f24dbf64bd2df6https://doi.org/10.1136/thx.37.12.893
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