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August 1, 1995Biochemistry

Rate-limiting mechanisms of exchange reactions in the cardiac sarcolemma Na+-Ca2+ exchanger

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Population

Cardiac sarcolemma vesicles

Comparison

Variations in temperature, pH, voltage, and K+… vs Different experimental conditions

Design

Preclinical

Authors

DKDaniel KhananshviliTel Aviv UniversityGSGilat ShaulovTel Aviv UniversityEWEvelyne Weil-MaslanskyTel Aviv University

Discussion

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Implication

May refine cardiac ion transport models; leaves open validation in intact cells and therapeutic relevance.

Structured PICO

P
Population
Cardiac sarcolemma vesicles
I
Intervention
Variations in temperature (6-45 degrees C), pH (5.0-9.7), voltage, and K+ concentration
C
Comparator
Different experimental conditions (e.g., K+-free medium vs K+ added, varying pH and temperatures)
O
Outcome
Initial rates (t = 1 s) of Nai- and Cai-dependent 45Ca uptakessurrogate

This preclinical study elucidates that voltage-sensitive Na+ efflux and Ca2+ efflux are the rate-limiting steps for Na+-Ca2+ and Ca2+-Ca2+ exchanges, respectively, in cardiac sarcolemma vesicles under physiological pH.

Cite This Study

Khananshvili et al. (1995) studied this question.

synapsesocial.com/papers/6a766e2fd3a6aa87c6bd30d3https://doi.org/10.1021/bi00032a024
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The cardiac sodium-calcium exchanger: Relative rates of calcium and sodium movements and their modulation by protonation-deprotonation of the carrier1994 · 23 citations
  2. 2Time-Resolved Monitoring of Electrogenic Na<sup>+</sup>−Ca<sup>2+</sup>Exchange in the Isolated Cardiac Sarcolemma Vesicles by Using a Rapid-Response Fluorescent Probe1999 · 32 citations
  3. 3Steady-state and dynamic properties of cardiac sodium-calcium exchange. Ion and voltage dependencies of the transport cycle.1992 · 149 citations
  4. 4Control of the Na-Ca exchanger in isolated heart cells. II. Beat-dependent activation in normal cells by intracellular calcium.1991 · 17 citations
  5. 5Na+-Ca2+ exchange contributes to increase of cytosolic Ca2+ concentration during depolarization in heart muscle1986 · 49 citations