Why the study?
The impact of neutrophil extracellular traps on macrophage polarization, acute cardiac inflammation, and subsequent cardiac healing after acute myocardial infarction was not fully understood.
Population
PAD4-/- and WT mice subjected to permanent ligation of the left anterior descending artery
Comparison
PAD4-/- mice vs WT mice
Design
Preclinical animal and in vitro experimental study
Follow-up
Day 21
Authors
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May caution against PAD4 targeting post-MI; leaves open NETs' reparative role in human cardiac healing.
PAD4 deficiency aggravates acute inflammation and tissue damage post-MI due to the lack of NETs, which normally support anti-inflammatory macrophage polarization.
Eghbalzadeh et al. (2019) studied this question.
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