Why the study?
Does ticlopidine-pentoxifylline combination prevent cerebrovascular accidents and improve atherosclerosis compared to aspirin-dipyridamole-buflomedil or buflomedil-placebo in patients with atherosclerosis?
Population
79 patients with atherosclerosis
Comparison
Ticlopidine-pentoxifylline combination vs Aspirin-dipyridamole-buflomedil combination and…
Design
RCT, randomized, double-blind
Authors
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Supports ticlopidine-pentoxifylline for cerebrovascular prevention in atherosclerosis; extends RCT comparisons of antiplatelet-vasodilator combinations.
Does ticlopidine-pentoxifylline combination prevent cerebrovascular accidents and improve atherosclerosis compared to aspirin-dipyridamole-buflomedil or buflomedil-placebo in patients with atherosclerosis?
Ticlopidine-pentoxifylline combination therapy may be effective in improving atherosclerosis hemodynamics and preventing cerebrovascular accidents compared to other antiplatelet/vasodilator combinations.
Apollonio et al. (1989) studied this question.
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