Population
Microdissected tissue from atherosclerotic lesions and nonatherosclerotic intima and media
Design
Review
Authors
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Challenges mutation-driven models of plaque clonality; leaves open developmental cell patch origins for mechanistic validation.
Atherosclerotic plaque clonality may arise from the expansion of preexisting developmental cell patches rather than solely from novel mutations or viral events.
Schwartz et al. (1998) studied this question.
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