Why the study?
Does acute pressure overload alter phosphorus energy metabolites and limit RV contractile function in a porcine model?
Does acute pressure overload alter phosphorus energy metabolites and limit RV contractile function in a porcine model?
In a porcine model, acute moderate RV pressure overload decreases the PCr/ATP ratio without ischemia, while maximal pressure overload depletes RV coronary flow reserve, accompanying the onset of RV failure.
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Implicates energetics and flow reserve in acute RV failure; leaves open translation to human pressure-overload states.
Schwartz et al. (1992) studied this question.
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