Reflex increase in blood pressure during the intracoronary administration of adenosine in man.

46 patients, comprising 26 patients with innervated hearts undergoing diagnostic cardiac catheterization for evaluation of chest pain syndromes (mean age 48, 20 men) and 20 cardiac transplant recipients with denervated hearts (mean age 44, 15 men). Excluded: unstable angina, recent myocardial infarction, valvular heart disease, elevated left ventricular filling pressures, impaired left ventricular systolic function, or focal LAD stenosis ≥50%.

Intracoronary infusion of adenosine (0.022-2.2 mg/min) into the left anterior descending (LAD) coronary artery via Doppler catheter.

Control infusion (0.9% sodium chloride) and right atrial infusion of adenosine (2.2 mg/min) in a subset of 5 patients.

Changes in systolic and diastolic arterial blood pressure and heart rate.surrogate