What question did this study set out to answer?

To determine how ferroptosis-related gene expression profiles correlate with overall survival, immune infiltration, and therapy responsiveness in gastrointestinal adenocarcinomas.

January 1, 2025Translational Gastroenterology and HepatologyOpen Access

Pan-gastrointestinal adenocarcinoma analysis uncovers the prognostic and immune correlates of ferroptosis-related genes

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Authors

XDXiaochuan DongWuhan Union Hospital YXYanyan XieNorth China University of Science and Technology Affiliated Hospital WCWenxi ChenSecond Affiliated Hospital of Zhejiang University

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Implication

Transcriptomic study reveals that a ferroptosis score predicts survival and immunotherapy response in gastrointestinal adenocarcinomas, highlighting its value as a clinical biomarker.

Key Points

To determine how ferroptosis-related gene expression profiles correlate with overall survival, immune infiltration, and therapy responsiveness in gastrointestinal adenocarcinomas.
Extracted transcriptomic, genomic, and clinical data from TCGA, CCLE, GDSC, and four GEO validation datasets (GSE84437, GSE17536, GSE103479, and GSE19417).
Formulated a ferroptosis-score using gene set variation analysis (GSVA) and evaluated drug sensitivity and immunotherapy efficacy using GDSC and the PRJEB25780 cohort.
Higher ferroptosis-scores were significantly associated with improved overall survival in the TCGA cohort (HR 0.67, 95% CI: 0.52–0.87, P=0.003) and across four GEO cohorts (GSE17536: HR 0.57, P=0.03; GSE19417: HR 0.53, P=0.047; GSE84437: HR 0.68, P=0.004; GSE103479: HR 0.55, P=0.03).
High ferroptosis-scores correlated with DNA damage repair pathway activation and resistance to cisplatin chemotherapy.
Low ferroptosis-score tumors displayed elevated PD-(L)1 and CTLA-4 expression, denser CD8+ T-cell infiltration, and improved treatment response to pembrolizumab monotherapy.

Cite This Study

Dong et al. (2025) studied this question.

synapsesocial.com/papers/6a766eba232067cbf2ec0666 https://doi.org/10.21037/tgh-24-15

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Implication

Transcriptomic study reveals that a ferroptosis score predicts survival and immunotherapy response in gastrointestinal adenocarcinomas, highlighting its value as a clinical biomarker.

Pan-gastrointestinal adenocarcinoma analysis uncovers the prognostic and immune correlates of ferroptosis-related genes

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Member takes

Implication

Key Points

Cite This Study

Pan-gastrointestinal adenocarcinoma analysis uncovers the prognostic and immune correlates of ferroptosis-related genes

Discussion

Member takes

Implication

Key Points

Cite This Study

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