Key result
A ferroptosis scoring model based on 60 genes accurately distinguished and predicted survival prognosis and immunotherapy efficacy in breast cancer patients.
Why the study?
Most genes regulating or marking ferroptosis relate to poor cancer prognosis, but their comprehensive relationship with tumor-infiltrating immune cells, mutation, and immunotherapy in breast cancer required evaluation.
Population
Breast cancer samples from TCGA and GEO databases
Comparison
Ferroptosis gene clusters and groups defined by a ferroptosis score model
Design
Bioinformatic and genomic cohort analysis
Authors
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May support ferroptosis gene profiling for cancer prognosis; leaves open therapeutic relevance pending prospective validation.
Observational
A novel ferroptosis scoring model can predict survival prognosis and immunotherapy efficacy in breast cancer patients.
He et al. (2022) conducted an observational in Breast cancer. Ferroptosis score (ferr.score) was evaluated on Survival prognosis and immunotherapy efficacy. A ferroptosis scoring model based on 60 genes accurately distinguished and predicted survival prognosis and immunotherapy efficacy in breast cancer patients.
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