Transforming oncogenes selectively suppress one type of voltage-sensitive calcium channel in 3T3 fibroblasts, suggesting a potential role in regulating calcium-sensitive cellular processes.
May link oncogene activity to altered calcium signaling in fibroblasts; leaves open relevance to human cancers or targeted therapies.
Patch clamp recordings of whole-cell and single channel currents revealed the presence of two voltage-sensitive calcium channel types in the membrane of 3T3 fibroblasts. The two calcium channel types were identified by their unitary properties and pharmacological sensitivities. Both calcium channel types were present in all control 3T3 cells, but one type was selectively suppressed in 3T3 cells that had been transformed by activated c-H-ras, EJ-ras, v-fms, or polyoma middle T oncogenes. The presence of voltage-sensitive calcium channels in these nonexcitable cells and the control of their functional expression by transforming oncogenes raises questions about their role in the control of calcium-sensitive processes such as cell motility, cytoskeletal organization, and cell growth.
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Chen et al. (1988) studied this question.
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