Key result
Rous sarcoma virus transformation induces a noninactivating, Ca2+-dependent K+ current unlike normal fibroblasts.
Population
Chicken embryo fibroblasts (CEFs)
Comparison
Transformation by Rous sarcoma virus or… vs Nontransformed CEFs or CEFs infected with RAV5
Design
Preclinical
Authors
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pp60v-src may remodel K+ currents in transformed fibroblasts; leaves open ion channel roles in oncogenesis and need for mammalian validation.
The oncogene product pp60v-src modulates existing K+ channel proteins, leading to profound electrophysiological alterations in RSV-transformed CEFs.
Repp et al. (1993) studied Rous sarcoma virus-transformed chicken embryo fibroblasts. Rous sarcoma virus (RSV) transformation vs. Nontransformed chicken embryo fibroblasts was evaluated on Potassium current properties. Rous sarcoma virus transformation of chicken embryo fibroblasts induced a noninactivating, Ca2+-dependent K+ current sensitive to charybdotoxin (IC50 19 nM), unlike normal fibroblasts.
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