September 28, 2016The Journal of Maternal-Fetal & Neonatal MedicineOpen Access

Early second-trimester plasma levels of NT-proBNP in women who subsequently develop early-onset preeclampsia

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Why the study?

Does early second-trimester maternal plasma NT-proBNP predict early-onset preeclampsia?

Structured PICO

Does early second-trimester maternal plasma NT-proBNP predict early-onset preeclampsia?

Population

59 pregnant women in the early second-trimester, including 16 who later developed early-onset preeclampsia (gestational age 34 wk + 0 or earlier) and 43 with uncomplicated pregnancy outcomes

Intervention

Early second-trimester maternal plasma NT-proBNP measurement

Outcome

Prediction of early-onset preeclampsia (gestational age 34 wk + 0 or earlier)surrogate

Early second-trimester NT-proBNP levels are not a useful predictive biomarker for the development of early-onset preeclampsia.

Discussion

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Implication

Early NT-proBNP does not differ before early-onset preeclampsia; leaves open whether other biomarkers predict this outcome in prospective studies.

Cite This Study

Junus et al. (2016) studied this question.

synapsesocial.com/papers/6a767d8a46f688d752c44913 https://doi.org/10.1080/14767058.2016.1241992

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Implication

Early NT-proBNP does not differ before early-onset preeclampsia; leaves open whether other biomarkers predict this outcome in prospective studies.