UBC-Nepal Expedition: imposed oscillatory shear stress does not further attenuate flow-mediated dilation during acute and sustained hypoxia
Why the study?
Does experimentally induced oscillatory shear stress reduce flow-mediated dilation during acute and sustained hypoxia in healthy lowlanders?
Population
Healthy lowlanders (n=15), mean age 30 ± 6 years.
Comparison
30-min distal cuff inflation to provoke… vs The same 30-min distal cuff inflation performed…
Design
Other
Authors
Discussion
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Member takes
Implication
Hypoxia does not heighten endothelial susceptibility to OSS in healthy lowlanders; leaves open effects in patients or with prolonged exposure.
Structured PICO
Does experimentally induced oscillatory shear stress reduce flow-mediated dilation during acute and sustained hypoxia in healthy lowlanders?
P
Population
Healthy lowlanders (n=15), mean age 30 ± 6 years.
I
Intervention
30-min distal cuff inflation (75 mmHg) to provoke oscillatory shear stress (OSS) in the brachial artery, performed during acute hypoxia (11% O2 for 20 min) and sustained hypoxia (5-7 days after a 9-day ascent to 5,050 m).
C
Comparator
The same 30-min distal cuff inflation (OSS intervention) performed during normoxia at sea level.
O
Outcome
Endothelial function assessed by reactive hyperemia flow-mediated dilation (FMD) before and after each intervention.surrogate
While experimentally induced oscillatory shear stress impairs endothelial function in normoxia, it does not further worsen flow-mediated dilation during acute or sustained hypoxia.
Cite This Study
Tremblay et al. (2018) studied this question.