Key result
Plasma volume expansion increases the flow-mediated dilation slope by ~44% in men under hypobaric hypoxia.
Why the study?
The study was conducted to examine the impact of hypobaric hypoxia and hemoconcentration on blood viscosity, shear stress, and endothelial function, as well as the effects of plasma volume expansion.
Does hypobaric hypoxia and subsequent plasma volume expansion alter endothelial function, blood viscosity, and shear stress in healthy male lowlanders?
Population
Men
Comparison
Hypobaric hypoxia and hemoconcentration vs normoxic control, and plasma volume expansion
Design
Normoxic crossover study
Follow-up
4 days
Authors
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Shear stress may preserve endothelial function in hypoxia; leaves open whether volume expansion benefits extend beyond healthy men.
RCT (n=11)
Single-blind
Crossover
No
Does hypobaric hypoxia and subsequent plasma volume expansion alter endothelial function, blood viscosity, and shear stress in healthy male lowlanders?
p-value: p=0.023
Endothelial function is preserved during hypobaric hypoxia in healthy men, likely due to vasoprotective increases in shear stress, and plasma volume expansion selectively improves sustained shear stress-mediated dilation.
Tremblay et al. (2020) conducted an RCT in Healthy (n=11). Hypobaric hypoxia and plasma volume expansion vs. Normoxia was evaluated on Stimulus-response slope of increases in shear stress to vasodilation during SS-FMD following plasma volume expansion (p=0.023). Plasma volume expansion increased the stimulus-response slope of sustained stimulus flow-mediated dilation by 44% in healthy men exposed to hypobaric hypoxia.
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