Why the study?
Myocardial infarction increases heart valve thickness and remodeling, and post-MI hemodynamic disturbances may affect aortic valve pathology, prompting investigation into the effects of StemBell therapy on the aortic valve after MI.
Does StemBell therapy reduce macrophages in atherosclerotic aortic valves after myocardial infarction?
Does StemBell therapy reduce macrophages in atherosclerotic aortic valves after myocardial infarction?
StemBell therapy may reduce inflammation and macrophage infiltration in atherosclerotic aortic valves following myocardial infarction in a preclinical model.
May attenuate post-MI aortic valve remodeling; leaves open therapeutic extension of StemBell beyond root plaques.
Previously, we have shown that StemBell therapy (i.e. mesenchymal stem cell-microbubble complexes subjected to ultrasound) reduced plaque inflammation and plaque destabilization in the aortic root, and thereby inhibited atherosclerosis exacerbation after myocardial infarction (MI). MI also has an effect on heart valves as it increases valve thickness and remodeling. Moreover, hemodynamic disturbances following MI have also been suggested to affect aortic valve (AV) pathology. Therefore, we have analyzed StemBell therapy on AV after MI.
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Broekhoven et al. (2020) studied this question.
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