Why the study?
Does propranolol therapy increase the risk of subsequent antidepressant use compared to diuretics or other antihypertensives in new users?
Does propranolol therapy increase the risk of subsequent antidepressant use compared to diuretics or other antihypertensives in new users?
Propranolol use in younger patients is associated with an increased risk of subsequent antidepressant use compared to diuretics, though this may not be solely due to depressive side-effects.
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Propranolol initiation was associated with doubled antidepressant use in young adults versus diuretics; hypothesis-generating for depressive effects and needs randomized confirmation.
Johnson et al. (1997) studied this question.
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