Population
human hepatoma cells (HepG2)
Comparison
reporter constructs containing human… vs reporter constructs containing human…
Design
Preclinical
Authors
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May support sex-specific angiotensinogen regulation by estrogen; leaves open clinical relevance in human hypertension pending further studies.
The C/A polymorphism at -20 of the human angiotensinogen gene may modulate its expression in a sex-specific manner, with the A allele responding to estrogen.
Zhao et al. (1999) studied this question.
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