Key result
A common variant in the proximal promoter of the angiotensinogen gene, an adenine instead of a guanine at position -6, is associated with essential hypertension and significantly increases basal transcription in vitro.
Why the study?
Is a nucleotide substitution in the angiotensinogen gene promoter associated with essential hypertension and altered basal transcription?
Is a nucleotide substitution in the angiotensinogen gene promoter associated with essential hypertension and altered basal transcription?
p-value: p=2.4 x 10^-6
A specific nucleotide substitution in the angiotensinogen gene promoter is associated with essential hypertension and alters basal transcription, providing insight into genetic predispositions to the disease.
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Highlights potential genetic predisposition to hypertension; hypothesis-generating for promoter variant effects in vivo.
Inoue et al. (1997) studied Essential hypertension (n=547). Adenine at position -6 (A(-6)) in AGT promoter vs. Guanine at position -6 (G(-6)) was evaluated on Basal transcription rate in vitro (p=2.4 x 10^-6). A common variant in the proximal promoter of the angiotensinogen gene, an adenine instead of a guanine at position -6, is associated with essential hypertension and significantly increases basal transcription in vitro.
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