Why the study?
Are mutations near the transcription start site of the human angiotensinogen gene associated with increased blood pressure and plasma angiotensinogen concentrations?
Population
274 subjects recruited from an outpatient clinic
Design
Cross-sectional
Authors
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Supports promoter variant roles in hypertension risk; extends molecular evidence but leaves open causality and clinical utility.
Are mutations near the transcription start site of the human angiotensinogen gene associated with increased blood pressure and plasma angiotensinogen concentrations?
Mutations near the transcription start site of the angiotensinogen gene (G-6A and T+68C) are significantly correlated with increased systolic and diastolic blood pressures, suggesting a genetic mechanism for primary hypertension.
Ishigami et al. (1999) studied this question.
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