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April 22, 2005Clinical and Experimental Pharmacology and Physiology

A Haplotype of the Angiotensinogen Gene Is Associated With Hypertension in African Americans

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Why the study?

Is the AGT gene haplotype containing -217A associated with hypertension in African Americans?

Population

African American hypertensive patients and in vitro reporter constructs

Comparison

Presence of allele A at -217 of the human… vs Other alleles (e.g., allele G at -217)

Design

Other

Authors

AKAshok KumarGovernment Medical CollegeYLYanna LiTianjin Huanhu HospitalSPSai PatilNew York Medical College

Discussion

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Implication

Supports AGT -217A as a hypertension candidate in African Americans; leaves open clinical translation pending replication.

Structured PICO

Is the AGT gene haplotype containing -217A associated with hypertension in African Americans?

P
Population
African American hypertensive patients and in vitro reporter constructs
I
Intervention
Presence of allele A at -217 of the human angiotensinogen (AGT) gene promoter (and associated haplotype -217A, -532T, -793A, -1074T)
C
Comparator
Other alleles (e.g., allele G at -217)
O
Outcome
Frequency of allele A at -217 in hypertensive patients and promoter activitysurrogate

The AGT haplotype containing -217A, -532T, -793A, and -1074T is associated with increased gene transcription and may play a role in hypertension among African Americans.

Cite This Study

Kumar et al. (2005) studied this question.

synapsesocial.com/papers/6a8bd090fe910689a2893c9fhttps://doi.org/10.1111/j.1440-1681.2005.04217.x

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Lack of Association of 3 Functional Gene Variants With Hypertension in African Americans2000 · 102 citations
  2. 2Linkage of the angiotensinogen gene locus to human essential hypertension in African Caribbeans.1995 · 191 citations
  3. 3A nucleotide substitution in the promoter of human angiotensinogen is associated with essential hypertension and affects basal transcription in vitro.1997 · 550 citations
  4. 4Role of C/A Polymorphism at −20 on the Expression of Human Angiotensinogen Gene1999 · 125 citations
  5. 5A -Acting DNA Element Located between TATA Box and Transcription Initiation Site Is Critical in Response to Regulatory Sequences in Human Angiotensinogen Gene1996 · 83 citations