Key result
The A-20C mutation in the human angiotensinogen gene showed a weak but significant correlation with plasma AGT concentrations (P=0.047) and essential hypertension (P=0.049).
Why the study?
Is the A-20C mutation in the human AGT gene associated with increased plasma AGT concentrations and essential hypertension?
Population
188 subjects receiving no antihypertensive medication and 234 subjects
Comparison
A-20C mutation in the 5' upstream core promoter… vs Wild-type (absence of A-20C mutation)
Design
Cross-sectional
Authors
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No immediate clinical implications for hypertension care; leaves open AGCE1-AGCF1 mechanistic validation in genetic studies.
Cross-Sectional
Is the A-20C mutation in the human AGT gene associated with increased plasma AGT concentrations and essential hypertension?
p-value: p=0.047 (AGT), 0.049 (hypertension)
The A-20C mutation in the human AGT gene promoter region is weakly but significantly associated with elevated plasma AGT concentrations and essential hypertension.
Ishigami et al. (1997) conducted a cross-sectional in Essential hypertension. A-20C mutation in the human angiotensinogen gene vs. Absence of A-20C mutation was evaluated on Correlation with plasma AGT concentrations and essential hypertension (p=0.047 (AGT), 0.049 (hypertension)). The A-20C mutation in the human angiotensinogen gene showed a weak but significant correlation with plasma AGT concentrations (P=0.047) and essential hypertension (P=0.049).
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